For the convenience of the vast majority of experimental scientists, a web server for the iDHS-EL predictor has been established. To our best knowledge, it is the first web-server ever established for predicting the DHSs in human genome. Moreover, to maximize users' convenience, a step-by-step guide on how to use it to get the desired results is given below.

Step 1. Open the web server at http://bliulab.net/iDHS-EL/ and you will see its top page. Click on the Read Me button to see a brief introduction about the predictor and the caveat when using it.

Step 2. You can either type or copy/paste the query DNA sequence into the input box, or directly upload your input data by the Browse button. The input sequence should be in the FASTA format. For the examples of DNA sequences in FASTA format can be seen by clicking on the Example button right above the input box.

Step 3. Click on the Submit button to see the predicted results. For example, if you use the four query DNA sequences in the Example window as the input, after clicking the Submit button, you will see the following shown on the screen of your computer: (1) the 1^st query DNA sequence (misc_ppid_8090) is of DHS; (2) the 2^nd query sequence (misc_ppid_7576) is of DHS; (3) the 3^rd query sequence (misc_ppid_7593) is of non-DHS; (4) the 4^th query sequence (misc_ppid_6460) is of non-DHS. All these predicted results are fully consistent with the experimental observations.

Step 4. Click on the Benchmark Data button to download the datasets used to train and test the model.